Protein Details: Neuronal acetylcholine receptor subunit alpha-7
Protein ID
ICDB_Pro_0564
Protein Name
Neuronal acetylcholine receptor subunit alpha-7
Gene Name
Chrna7; Acra7
Organism
Mus musculus (Mouse)
Length
502 amino acids
AlphaFoldDB
AF-P49582-F1-model_v4.pdb
Function
Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium; the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear; this leads to a reduction in basilar membrane motion; altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion. .
Sequence
PDB Structures
Ligand Binding
Binding Site
SITE 86: "Key residue important for potent inhibition of the CHRNA9-CHRNA10 receptor by the alpha-conotoxin RgIA (AC P0C1D0)"; SITE 146: "Key residue important for potent inhibition of the CHRNA9-CHRNA10 receptor by the alpha-conotoxin RgIA (AC P0C1D0)"
Disease
Location
Detected in the nasal epithelium; in the outer hair cells of the cochlea; in the pars tuberalis of the hypophysis; and in the developing muscle of the tongue. Also expressed in the neurons of dorsal root ganglia.
DOI ID
10.1016/0092-8674(94)90555-x; 10.1016/s0378-5955(99)00214-2; 10.1016/s0028-3908(00)00124-6; 10.1073/pnas.051622798; 10.1016/s0378-5955(02)00380-5; 10.1016/s0306-4522(02)00274-9; 10.1124/mol.65.2.453; 10.1111/j.1471-4159.2012.07867.x; 10.1016/j.jmb.2008.01.082; 10.1124/mol.114.096511; 10.1124/mol.114.096511err
RefSeq
NP_075219.1